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Psychological Effects of Statins and Other Medications

Posted on 24th December 2020

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I saw a very interesting report on the BBC about the psychological effects of medications.


The first part of the article focuses on the side-effects of statins (I am interested, since I was put back on statins in June), which apparently can make you bad tempered and aggressive. When discussing the report with Sheryl, she told me that I had definitely become more grumpy since starting the statins again, but luckily not as bad as some cases described in the BBC report (broken marriages, destroyed careers, and a surprising number of men who have come unnervingly close to murdering their wive). It turns out that there is quite a lot of research that shows that reductions in cholesterol levels make people and animals more aggressive.

Until now the main issue that I had with statins was having to give up grapefruit; the reason why I stopped taking them before. It seems that statins' incompatibility with grapefruit is just the thin end of the wedge.


Requip, a drug to treat (not to cure) the symptoms of Parkinson's was blamed for turning a man "into a gambler and gay sex addict, and was responsible for risky behaviours that had led to him being raped".


There's strong evidence that the drug L-dopa, used to treat Parkinson’s disease, increases the risk of Impulse Control Disorders (ICDs), which make it more difficult to resist temptations and urges. Some patients suddenly start taking more risks, becoming pathological gamblers, excessive shoppers, and sex pests.


The anti-obesity drug Duromine was blamed in 2015 by a man who targeted young girls on the Internet. He used the argument that Duromine made him do it; that it reduced his ability to control his impulses.

Sedatives and Antidepressants

Every now and again, murderers try to blame sedatives or antidepressants for their offences.

Paracetamol (Acetaminophen)

Paracetamol is taken in enormous quantities around the world, not least because it is almost impossible to overdose, and it reduces fever and pain. Bizarrely, paracetamol can also make us feel better after a rejection.

A study revealed that paracetamol significantly reduces our ability to feel positive empathy. "Empathy doesn’t just determine if you’re a 'nice' person, or if you cry while you're watching sad movies. The emotion comes with many practical benefits, including more stable romantic relationships, better-adjusted children, and more successful careers – some scientists have even suggested that it's responsible for the triumph of our species."

Asthma Medications

It seems that it has been known for a while that the medications used to treat asthma are sometimes associated with behavioural changes, such as an increases in hyperactivity and the development of ADHD (Attention Deficit Hyperactivity Disorder) symptoms. This is in addition to a recently discovered connection between these two conditions, which means that having one increases the risk of having the other by around 50%.


There are a few problems around this issue.

  1. Patients often don't recognise the psychological side-effects of medications, and even if they do, they don't report them.
  2. Doctors often don't listen to patients' reports of psychological side-effects of drugs, so the problems are under-reported and usually there is no action taken to reduce or eliminate these effects.
  3. There is not much research into psychological side-effects, because they are hard to measure; researchers and the organisations who fund them prefer research into more concrete physical symptoms.

We should therefore assume that psychological side-effects might be more widespread and more severe than this report suggests. Let's hope that more research is done in this area.